수면정신생리

수면정신생리 (29권1호 1-3)

Relationship Between Sleep and Alzheimer’s Dementia

수면과 알츠하이머 치매의 관계

Kyoung Hwan Lee,1 Ho Chan Kim2

Department of Psychiatry, Bong Seng Memorial Hospital, Busan, Korea1, Department of Psychiatry, Gosin University Gospel Hospital, Busan, Korea2

Abstract

Sleep is associated with Alzheimer’s dementia. Many previous researches have shown that inadequate sleep is one of the risk factors that predict Alzheimer’s dementia. The causal mechanism of this association is not clear. Slow wave sleep and REM sleep are critical stages in memory consolidation, and by sequential hypothesis both stages are important. Deposition of amyloid beta and tau, the main pathology of Alzheimer’s dementia, are also associated with sleep. This review provides the association of sleep and Alzheimer’s dementia, and future research is necessary to examine the specific mechanism of this association between sleep and Alzheimer’s dementia, which may lead to an early intervention in sleep. Sleep Medicine and Psychophysiology 2022；29(1)：1-3

Keywords

Alzheimer; Amyloid beta; Dementia; Sleep; Tau.